RECOMMENDED DOSING
RELYVRIO is an oral therapy that can be taken by mouth or through a feeding tube.
FIRST 3 WEEKS
1 packet per day
AFTER 3 WEEKS
Take 2 packets per day: 1 packet in the morning and 1 packet at night
What to do if you miss a dose
If you forget to take one or more doses of RELYVRIO, you should take your next dose at the normal time and in the normal amount. You should not take more than what is prescribed by your doctor.
RELYVRIO and foods/antacids
Avoid taking RELYVRIO with antacids that contain aluminum. RELYVRIO should be taken before a snack or meal.
How to store RELYVRIO
RELYVRIO should be stored at room temperature (between 68° F and 77° F) and protected from moisture. Keep out of reach of children.
STEP-BY-STEP INSTRUCTIONS FOR TAKING RELYVRIO
This quick overview offers general recommendations about how to take RELYVRIO. Be sure to speak with your doctor, who is always the best source for treatment information, before beginning RELYVRIO.
1
Use scissors to open the packet of RELYVRIO.
2
Pour contents of packet into a cup.
3
Add approximately 1 cup (8 oz) of room temperature water.
Do not mix RELYVRIO with liquid other than water.a
4
Stir vigorously until dissolved.
This may require significant stirring or gentle crushing.
5
Take each dose of RELYVRIO in its entirety within 1 hour of dissolving.
You can drink it or take it via a feeding tube.
*
*Optional for feeding tube administration:
Use a clean gravity bag or syringe to administer RELYVRIO through the feeding tube.
After each dose, it’s important to flush the feeding tube with warm water as directed by your doctor.
a When mixed, the solution may appear cloudy and/or contain residue.
Download and print these instructions for easy reference
WHAT TO EXPECT WHEN TAKING RELYVRIO
This useful information can help you start on your RELYVRIO treatment journey. It’s also important to know that ALS can affect people differently. An individual’s response to ALS treatments—including RELYVRIO—may vary. Your doctor will explain the benefits and side effects associated with taking RELYVRIO.
RELYVRIO IS NOT A CURE
While RELYVRIO will not stop ALS, it may help slow down disease progression.
WHAT TO KNOW ABOUT SIDE EFFECTS
In the CENTAUR clinical trial for RELYVRIO, the most common side effects were diarrhea, abdominal pain, nausea, and upper respiratory tract infection.
MANAGING THE TASTE
The taste of RELYVRIO can vary from person to person. Talk to your doctor about managing the taste of RELYVRIO.
- When mixed with water, RELYVRIO may have a fruity smell, but that may not reflect its actual taste
- RELYVRIO may have a bitter aftertaste. In the clinical trial, participants were allowed to try to lessen or remove the bitter aftertaste by:
- Using mint-flavored mouth strips or mouth spray immediately before or after taking RELYVRIO
- Eating a small snack or honey after taking RELYVRIO
- Drinking milk after taking RELYVRIO
- Avoiding fruit juice immediately afterwards, as it can make the aftertaste worse
RELYVRIO AND OTHER TREATMENTS
RELYVRIO may be taken alone or with other FDA-approved treatments for ALS. Before taking any medications, talk to your doctor.
IF RELYVRIO SEEMS RIGHT FOR YOU
First, talk to your doctor to determine if RELYVRIO may serve as a part of you and your doctor’s plan to manage ALS.
If you and your doctor decide that RELYVRIO is right for you, it’s important to work together to fill out the RELYVRIO Enrollment Form, which serves as your prescription for RELYVRIO. It may take some time between submitting the RELYVRIO Enrollment Form and getting RELYVRIO delivered to your home, so it’s important to reach out to your doctor and start the enrollment process as soon as possible.
Download this information.
